MedComm | Cell Death主题专刊等您免费阅读

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近期，MedComm编辑准备了主题为Cell Death的专刊，包括10篇发表在期刊上的高质量论文，供专家学者和研究生们免费阅读！

The role of necroptosis in disease and treatment

Xiaoxiao Liu, Xin Xie, Yuanyuan Ren, Zhiying Shao, Nie Zhang, Liantao Li, Xin Ding, Longzhen Zhang

First Published: 20 December 2021

Necroptosis is activated by a unique caspase-independent signaling pathway and mainly relies on RIPK1/RIPK3/MLKL complex. Over the past decade, necroptosis has been found widely involved in life process of human beings and animals. In this article, we attempt to explore therapeutic prospects of the necroptosis regulators in health maintenance and disease treatment by describing the molecular mechanism of necroptosis and the role it played in disease and tissue homeostasis, summarizing the research and clinical applications of corresponding inhibitors and inducers which include small molecule inhibitors, chemicals, Chinese herbal extracts, and biological agents in the treatment of a variety of diseases including cancer, inflammation, infection, ischemia-reperfusion injury, neurodegenerative diseases in various organs including cardiovascular, pulmonary, liver, pancreatic, renal, enteric, ocular, joint, and skin.

NF-κB signaling in inflammation and cancer

Tao Zhang, Chao Ma, Zhiqiang Zhang, Huiyuan Zhang, Hongbo Hu

First Published: 16 December 2021

This year (2021) marks the 35th anniversary of the discovery of NF-κB. With so many years of in-depth research on NF-κB, people have realized that the NF-κB signaling pathway plays an important role in inflammation, immunity, cell survival and proliferation. This review summarizes the relevant knowledge of the NF-κB signaling pathway, inflammation, and cancer. The progression of the translational study and drug development targeting NF-κB for inflammatory diseases and cancer treatment and the potential obstacles will also be discussed.

Sertaconazole provokes proapoptotic autophagy via stabilizing TRADD in nonsmall cell lung cancer cells

Wenhui Zhang, Li Zhou, Siyuan Qin, Jingwen Jiang, Zhao Huang, Zhe Zhang, Xiyu Zhang, Zheng Shi, Jie Lin

First Published: 16 December 2021

Sertaconazole promotes TRADD expression via stabilizing it from ubiquitination-mediated degradation, which induces Akt dephosphorylation and subsequent proapoptotic autophagy, thus suppressing NSCLC cell growth.

Autophagic activation of IRF-1 aggravates hepatic ischemia–reperfusion injury via JNK signaling

Shipeng Li, Jindan He, Hongwei Xu, Jiaxing Yang, Yutian Luo, Wenyue Song, Bingbing Qiao, Haiming Zhang

First Published: 11 February 2021

The expression of interferon regulatory factor-1 (IRF-1) is related to the high autophagy activity and aggravates the liver damage, which is offset by IRF-1 depletion in vivo or in vitro. IRF-1 can activate autophagy to aggravate hepatic ischemia–reperfusion via regulating JNK pathway.

Lomerizine 2HCl inhibits cell proliferation and induces protective autophagy in colorectal cancer via the PI3K/Akt/mTOR signaling pathway

Xiang-Peng Tan, Yan He, Yun-Na Huang, Can-Can Zheng, Jun-Qi Li, Qin-Wen Liu, Ming-Liang He, Bin Li, Wen-Wen Xu

First Published: 15 July 2021

Lomerizine 2HCl, which is an approved prophylactic drug for migraines, was selected for our studies. In vitro and in vivo functional assays were performed, and the data suggest that lomerizine 2HCl inhibits cell growth and promotes apoptosis in CRC cells. Moreover, lomerizine 2HCl inhibits cell migration and invasion of CRC. RNA sequencing analysis and Western blotting confirmed that lomerizine 2HCl can inhibit cell growth, migration, and invasion via the PI3K/AKT/mTOR signaling pathway and induces protective autophagy in CRC. Meanwhile, autophagy inhibition by 3-methyladenine (3-MA) increases lomerizine 2HCl-induced cell apoptosis. Taken together, these results suggest that lomerizine 2HCl is a potential therapeutic agent, and the combination of lomerizine 2HCl and autophagy inhibitors may serve as a novel strategy to increase the anticancer efficacy of agents in the treatment of CRC.

Lycopene antagonizes lead toxicity by reducing mitochondrial oxidative damage and mitochondria-mediated apoptosis in cultured hippocampal neurons

Mingyue Qu, Yanli Ni, Baoshi Guo, Xin Feng, Zheng Jiang

First Published: 27 August 2020

In this study, we demonstrated the neuroprotective effects of lycopene in primary cultured rat hippocampal neurons challenged with lead. The protective effects of lycopene may be attributable to its roles in reducing mitochondrial oxidative damage and mitochondria-mediated apoptosis.

Pulmonary Staphylococcus aureus infection regulates breast cancer cell metastasis via neutrophil extracellular traps (NETs) formation

Jia-Long Qi, Jin-Rong He, Cun-Bao Liu, Shu-Mei Jin, Rui-Yu Gao, Xu Yang, Hong-Mei Bai, Yan-Bing Ma

First Published: 30 July 2020

Neutrophils help cancer cells metastasis in distant organs. Clinical multidrug-resistant (MDR) S. aureus infection enhances cancer recurrence via orchestrating the NETosis network to promote metastasis. Targeting autophagy and/or NETs in bacterial infection may be useful for patient prognosis and may reduce metastasis.

Tyrosine phosphatase SHP2 exacerbates psoriasis-like skin inflammation in mice via ERK5-dependent NETosis

Yan Ding, Zijun Ouyang, Chenyang Zhang, Yuyu Zhu, Qiang Xu, Haiyan Sun, Jiao Qu, Yang Sun

First Published: 04 March 2022

Single-cell RNA sequencing and experimental verification were combined to announce that SHP2 aggravates psoriasis-like skin inflammation in mice via ERK5-dependent NETosis. During this process, inflammatory cytokines: TNF-α, IL-1β, IL-6, IL-17a, and CXCL-15 were infiltrated in skin and contributed to psoriasis. Our study provides evidence for the role of SHP2 in NETosis and psoriasis. SHP2 may be a potential therapeutic target for the treatment of psoriasis.

Clinical benefit of neoadjuvant anti-PD-1/PD-L1 utilization among different tumors

Zhiyang Li, Xin Wu, Yanjie Zhao, Yinan Xiao, Yunuo Zhao, Ting Zhang, Hui Li, Fushen Sha, Yating Wang, Lei Deng, Xuelei Ma

First Published: 11 March 2021

Twenty studies were included in this meta-analysis. The pooled CRR of triple-negative breast cancer and urothelial carcinoma was 0.569 (95% CI 0.514, 0.624) and 0.320 (95% CI 0.234, 0.407), respectively. The pooled MRR of lung cancer was 0.471 (95% CI 0.367, 0.575). In conclusion, neoadjuvant anti-PD-1/PD-L1 therapy received satisfactory clinical results in these tumors.

Programmed death-ligand 1 expression on CD22-specific chimeric antigen receptor-modified T cells weakens antitumor potential

Jie Liu, Fengjuan Zhang, Jian Yu, Qi Zhao

First Published: 29 May 2022

Engagement of CAR-T cells through PD-1/PD-L1 ligation. We speculate that PD-L1-expressed CAR- T cells lead to a suppressive signal by PD-1/PD-L1 engagement. From there, T cell-associated PD-L1 is a major therapeutic target of immune checkpoint blockade.

关于 MedComm

MedComm 是科研和教育领域的全球领导者——Wiley公司出版发行的全英文生物医学专业期刊（https://onlinelibrary.wiley.com/journal/26882663）, 被PubMed Central （PMC）、Emerging Sources Citation Index （ESCI）、Scopus、Directory of Open Access Journals (DOAJ) 等国际检索数据库收录。主编由英国牛津大学James Henderson Naismith教授（英国皇家科学院院士、英国皇家爱丁堡科学院院士）、耶鲁大学Günter P. Wagner教授（美国国家科学院院士、美国科学促进会院士、美国艺术与科学院院士）和四川大学华西医院生物治疗国家重点实验室魏于全教授（中国科学院院士）担任，副主编与编委由全球10多个国家的著名科学家构成。主编魏于全院士于2016年成功创办了Signal Transduction and Targeted Therapy (2021年影响因子38.104)。

MedComm 是同行评审的在线发表开放获取 (OA) 期刊，及时出版关于生物医学领域的基础研究与临床研究方面的工作，力争成为生物医学领域中具有国际影响力的高质量SCI学术期刊。本期刊发表论文类型包括综述（Review）、展望（Perspective）、研究论文（Research Article）、致编辑信函（Letter）、研究亮点（Research Highlight）等，对于重要的原创性成果采取“快速通道”模式，帮助作者以最快的速度发表文章，最快一周可接收，并于2020年至2022年之间免收论文出版费。此外，投稿时文章格式不限，正式接收发表时再按本期刊要求修改。

MedComm 竭诚欢迎生物医学领域的科研工作者、医生、研究生积极向期刊投稿！

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